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28759

Promising Antidiabetic and Wound Healing Activities of <i>Forsskaolea tenacissima</i> L. Aerial Parts.

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pharmacology and Toxicology

Abstract

The aim of present study was to evaluate antidiabetic activity of the total methanolic extract (TME) and different fractions of Forsskaolea tenacissima L. aerial parts with alloxan induced diabetic rats and evaluate wound healing activity with excision wound model in rats as well as determination of toxicological activity by lethal dose 50% (LD50). The ethyl acetate fraction showed a significant decrease in blood glucose level (36.00%, P<0.001) in comparison with glibenclamide (36.14%, P<0.001) as standard. The TME group showed marked increase in wound healing activity (97.9%, P<0.001) compared with Garamycin® ointment standard group (96.8%, P<0.001). The TME is safe due to the LD50 was 7 g/kg body weight.

DOI

10.21608/jabps.2019.7542.1034

Keywords

Forsskaolea tenacissima, Urticaceae, antidiabetic, Wound healing, Acute toxicity

Authors

First Name

Hamdy

Last Name

Assaf

MiddleName

K.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt

Email

hamdyss200@yahoo.com

City

-

Orcid

-

First Name

Alaa

Last Name

Nafady

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt

Email

alaa12nafady@yahoo.com

City

Assuit

Orcid

-

First Name

Ahmed

Last Name

Allam

MiddleName

E.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt

Email

aallam81@yahoo.co.uk

City

-

Orcid

-

First Name

Ashraf

Last Name

Hamed

MiddleName

N. E.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

ashrafnag@mu.edu.eg

City

Minia

Orcid

0000-0003-2230-9909

First Name

Mohamed

Last Name

Kamel

MiddleName

S.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt, Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt

Email

mskamel2@gmail.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

5127

Issue Date

2019-04-01

Receive Date

2019-01-23

Publish Date

2019-04-01

Page Start

72

Page End

76

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 2_Issue 2_Pages 72-76.pdf

PDF . 771.2kB

Link

https://jabps.journals.ekb.eg/article_28759.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=28759

Order

6

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Promising Antidiabetic and Wound Healing Activities of <i>Forsskaolea tenacissima</i> L. Aerial Parts.

Details

Type

Article

Created At

22 Jan 2023