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23094

Pyridazinones and pyrrolones as promising Scaffolds in Medicinal Chemistry

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

Pyridazinones and pyrrolones are important building blocks for some important drugs such as the naturally occurring antibacterial pyrrolone, althiomycin; the cardiotonic pyridazinones, pimobendan and levosimendan and the analgesic anti-inflammatory, emorfozan. Therefore, researchers all over the world paid attention to prepare various pyridazinones and pyrroolones derivatives. The variability in the biological response and ease of preparation from the corresponding furanones attracted attention of researchers to explore these two nuclei in the design and synthesis of different analogues with potential biological actvities. This review article focuses on different biological activities, structure activity relationship and mechanism of action of pyridazinones and pyrrolones derivatives.

DOI

10.21608/jabps.2018.5283.1023

Keywords

Pyridazinones, Pyrrolones, biological activities, Structure activity relationship

Authors

First Name

Mahmoud

Last Name

Abdelbaset

MiddleName

S

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt

Email

mahmoudsobhyorganic@yahoo.com

City

Assiut

Orcid

-

First Name

Mohamed

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

abulnil@hotmail.com

City

Minia

Orcid

-

First Name

Gamal

Last Name

Abuo-Rahma

MiddleName

El-Din A

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

gamal.aborahma@mu.edu.eg

City

Minia

Orcid

-

First Name

Mohammed

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt

Email

elbashamohammed@yahoo.com

City

Assiut

Orcid

-

First Name

Mostafa

Last Name

Abdelrahman

MiddleName

H

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt

Email

mhamed102004@yahoo.com

City

Assiut

Orcid

-

Volume

2

Article Issue

1

Related Issue

4340

Issue Date

2019-01-01

Receive Date

2018-09-26

Publish Date

2019-01-01

Page Start

19

Page End

28

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 2_Issue 1_Pages 19-28.pdf

PDF . 1.4MB

Link

https://jabps.journals.ekb.eg/article_23094.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=23094

Order

4

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Pyridazinones and pyrrolones as promising Scaffolds in Medicinal Chemistry

Details

Type

Article

Created At

22 Jan 2023