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14985

Design, Synthesis and Antifungal Activity of 1,2,4-Triazole/ or 1,3,4- Oxadiazole-ciprofloxacin hybrids

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

Due to the rapid development of fungal strains resistance, there is become great demand of newer agents that can withstand these resistant strains. This study involves design and synthesis of ciprofloxacin-triazole or ciprofloxacin-oxadiazole hybrids as potential antifungal agents for the purpose of synergism. Results showed that combination of 1,2,4-triazole or its bioisoster oxadiazole with ciprofloxacin can enhance antifungal activity against Candida albicans. The triazole hybrid 11 experienced comparable antifungal activity with itroconazole (MIC = 10.23 and 11.22 µg/mL, respectively). Molecular docking study showed that hybrid 11 can bind to the active site of lanosterol 14-α-demethylase CYP51 with reasonable docking scores.

DOI

10.21608/jabps.2018.3774.1013

Keywords

Fluoroquinolones, Azoles, Hybrids, Antifungal, Molecular docking

Authors

First Name

Hend

Last Name

Ezelarab

MiddleName

A. A.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

elizadoraprincess@yahoo.com

City

Minia

Orcid

-

First Name

Heba

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

hebahassan2009@live.com

City

Minia

Orcid

-

First Name

Samar

Last Name

Abbas

MiddleName

H.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

drsamar77@hotmail.com

City

Minia

Orcid

0000-0002-9586-2644

First Name

Rehab

Last Name

Abd El-Baky

MiddleName

M.

Affiliation

Department of Microbiology, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

rehabmhmoud16@gmail.com

City

Minia

Orcid

-

First Name

Gamal El-Din

Last Name

Aburahama

MiddleName

A.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

gamal.aborahma@mu.edu.eg

City

Minia

Orcid

-

Volume

1

Article Issue

2

Related Issue

3121

Issue Date

2018-10-01

Receive Date

2018-05-08

Publish Date

2018-10-01

Page Start

78

Page End

84

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 1_Issue 2_Pages 78-84.pdf

PDF . 955.0kB

Link

https://jabps.journals.ekb.eg/article_14985.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=14985

Order

5

Type

Short Communication.

Type Code

525

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Design, Synthesis and Antifungal Activity of 1,2,4-Triazole/ or 1,3,4- Oxadiazole-ciprofloxacin hybrids

Details

Type

Article

Created At

22 Jan 2023