Beta
ManageSearchChatDiscover
7672

NOS activity mediates some pathways in the protective effects of H2S in a model of diabetic nephrotpathy

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmacology and Toxicology

Abstract

Hydrogen sulfide (H2S) is one of the gaseous transmitters participating in different physiological and pathophysiological conditions. H2S possess vasoprotective, anti-inflammatory and anti-apoptotic properties so this study aimed to investigate the role of H2S in diabetic nephropathy and to examine the role of nitric oxide on H2S induced effects. The protective effects of H2S were tested by administration of sodium hydrogen sulfide (NaHS) an exogenous source of H2S. To study the role of nitric oxide, N-Nitro L-arginine methyl ester (L-NAME) was administered with NaHS. 
Diabetic rats showed signs of nephropathy evident in increased serum urea and creatinine levels. Treatment with an H2S donor (NaHS) exhibited protective effects against nephropathy induced by diabetes. NaHS diminished the elevated TNF-, NFB and caspase 3 expression induced by diabetes. Treatment with NaHS resulted in decreased MDA and H2O2 production with subsequent increase of SOD and CAT activity measured in kidney tissues. Administration of L-NAME in combination with NaHS diminished the protective effects of NaHS on inflammatory and oxidative status.
In conclusion, H2S has a protective role in diabetic nephropathy through its antioxidant, and anti-inflammatory on kidney tissue. This study provides anevidence that nitric oxide is important in mediating some of the protective effects of H2S.

Keywords

Cystathionine gamma lyase, High fat diet, NF-κB, streptozotocin

Authors

First Name

Aliaa

Last Name

Anter

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

aliaafath@yahoo.com

City

Minia

Orcid

-

First Name

Ashraf

Last Name

Taye

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

ashraf_taye70@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Moselhy

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ibn Sina University, Gaddah, Saudia Arabia

Email

m_moselhy64@yahoo.com

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

1479

Issue Date

2018-06-01

Receive Date

2018-04-22

Publish Date

2018-06-01

Page Start

26

Page End

32

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 1_Issue 1_Pages 26-32.pdf

PDF . 1.3MB

Link

https://jabps.journals.ekb.eg/article_7672.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=7672

Order

6

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

NOS activity mediates some pathways in the protective effects of H2S in a model of diabetic nephrotpathy

Details

Type

Article

Created At

22 Jan 2023