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Uncontrolled diabetes worsens cerebral ischemia-reperfusion injury in rats: insights into the involved mechanisms

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Pharmacology and Toxicology

Abstract

Uncontrolled diabetes mellitus (DM) has been associated with poor clinical outcomes in patients with ischemic stroke. Limited knowledge is available regarding the molecular mechanisms and the etiological complexity of both pathologies. Hence, this study aimed to investigate the interplay between long-term DM and ischemic stroke. A comparative study was held between long-term DM-induced adult male Wistar rats which were subjected to sham operation or global cerebral ischemia/reperfusion (I/R) injury on one hand, and adult male Wistar rats which were subjected to sham operation or global cerebral I/R injury on the other hand.
Results showed a disturbance in cerebral oxidative stress parameters (catalase, reduced glutathione and malondialdehyde) in diabetic rats compared to non-diabetic ones. Additionally, in comparison with sham diabetic group, diabetic I/R-injured rats showed up regulation of cerebral oxidative stress, caspase-3 and tumor necrosis factor- alpha (TNF-α) protein expression along with increase in carotid inducible nitric oxide synthase (iNOS) protein expression and downregulation of carotid endothelial nitric oxide synthase (eNOS) protein expression. However, no significant difference was observed in term of cerebral oxidative stress, cerebral caspase-3 and TNF-α protein expression upon comparing non-diabetic I/R-injured rats and diabetic rats subjected to cerebral I/R injury. Carotid vascular dysfunction is prominent in diabetic I/R-injured rats compared to non-diabetic rats with cerebral I/R injury. 
This study supposed that long term diabetes could exacerbate brain damage following global cerebral I/R injury via promoting inflammation, oxidative stress and vascular dysfunction. Diabetes-mediated vascular dysfunction in ischemic stroke warrants further experimental and clinical investigations to be fully elucidated.

Keywords

Uncontrolled diabetes, Global cerebral ischemia, Oxidative Stress

Authors

First Name

Rania

Last Name

Abdel-latif

MiddleName

G.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

dr_raniagalal@yahoo.com

City

-

Orcid

-

First Name

Gehan

Last Name

Heeba

MiddleName

H.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

ghhh70@yahoo.com

City

-

Orcid

-

First Name

Ashraf

Last Name

Taye

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

ashraf_taye70@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Khalifa

MiddleName

M. A.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

mmkhalifa2005@yahoo.com

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

1479

Issue Date

2018-06-01

Receive Date

2018-04-24

Publish Date

2018-06-01

Page Start

20

Page End

25

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 1_Issue 1_Pages 20-25.pdf

PDF . 937.4kB

Link

https://jabps.journals.ekb.eg/article_7671.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=7671

Order

5

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Uncontrolled diabetes worsens cerebral ischemia-reperfusion injury in rats: insights into the involved mechanisms

Details

Type

Article

Created At

22 Jan 2023