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7667

Synthesis and evaluation of the antioxidant activity of 1,2,4-triazole derivatives

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

A series of 1,2,4-triazole scaffold containing alkoxy moiety was synthesized by stirring compounds 3a-b or 7a-e at room temperature with different acid chlorides including 4-methoxy benzoyl chloride or 3,4,5-trimethoxybenzoyl chloride. The structure of the prepared compounds was confirmed using different spectroscopic techniques such as IR, 1HNMR, 13CNMR, Mass spectra and high resolution mass or elemental analysis. The synthesized compounds examined for their antioxidant activity using DPPH radical scavenging activity. Results indicated that most of the tested compounds exhibited moderate antioxidant activity. Compound 8b exhibited remarkable antioxidant activity with SC50 of 49.4M compared to trolox as a reference antioxidant agent at 10µM concentration.

Keywords

1, 2, 4-Triazole, Trolox and antioxidant activity

Authors

First Name

Hany

Last Name

ElSherief

MiddleName

A. M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-suef, Egypt, Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka 2014, Saudi Arabia

Email

drhanyabdeltawab@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

abulnil@hotmail.com

City

Minia

Orcid

-

First Name

Hamdy

Last Name

Abdel-Rahman

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni-suef, Egypt, Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, 71526-Assiut, Egypt

Email

hamdym01@yahoo.com

City

Assiut

Orcid

-

Volume

1

Article Issue

1

Related Issue

1479

Issue Date

2018-06-01

Receive Date

2018-04-12

Publish Date

2018-06-01

Page Start

1

Page End

5

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 1_Issue 1_Pages 1-5.pdf

PDF . 852.2kB

Link

https://jabps.journals.ekb.eg/article_7667.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=7667

Order

1

Type

Short Communication.

Type Code

525

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Synthesis and evaluation of the antioxidant activity of 1,2,4-triazole derivatives

Details

Type

Article

Created At

22 Jan 2023