204216

Monte carlo method estimates for internal dosimetry of well differentiated thyroid cancer patients

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Physics

Abstract

During radiotheranostic procedures, radioiodine-131(131I)activities deliver high internal gamma (ɣ) doses to the patient's organs. Thus, studying the internaldoses of patients is highly required to predict the stochastic or deterministiceffect of gamma radiation that may occur to patients.The objective ofthis study is to calculatethe internal doses for 11 critical organs or body tissues insideWell Differentiated Thyroid Cancer (WDTC) patients' bodiesafter receiving diagnostic and therapeutic 131I activitiesorally during 6days post administration.Internal effective doses delivered tocritical organs are estimated mathematically using Monte Carlo simulation model in which the actual geometry, volume, mass of organs and the source localization wasdesigned based onthe patients' CT images and Oak Ridge National Laboratory (ORNL) phantom.Thus, an average sized human phantom was constructed using MCNP5in whichtwo 131I sources were distributed in the abdominal and the thyroid gland sections.No significant radiation effect is expected during diagnostic procedures for the investigated organs including the thyroid itself. However,some deterministic effects or induction of thyroid cancer might be observedfor patients undergoing postoperative radiotherapy with largeprescribed activities.             

DOI

10.21608/absb.2021.93331.1133

Keywords

Radioiodine-131, Internal dosimetry, Monte Carlo, Well Differentiated Thyroid Cancer

Authors

First Name

Maged

Last Name

El-din

MiddleName

M. E.

Affiliation

Radiation Protection Department, Egyptian Nuclear and Radiological Regulatory Authority, Cairo, Egypt.

Email

magedmohamed78@gmail.com

City

cairo

Orcid

-

First Name

Amr

Last Name

Kany

MiddleName

M.

Affiliation

Faculty of science Al-Azhar University, Cairo, Egypt.

Email

amrkany@yahoo.com

City

cairo

Orcid

-

First Name

Eman

Last Name

Massoud

MiddleName

-

Affiliation

Jeddah International College, Jeddah, Saudi Arabia.

Email

e.massoud@jic.edu.sa

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Agamawi

MiddleName

Y.

Affiliation

Faculty of medicine Al-Azhar University, Cairo, Egypt.

Email

ahmedagamawi@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Ezz El-din

MiddleName

R.

Affiliation

Radiation Protection Department, Egyptian Nuclear and Radiological Regulatory Authority, Cairo, Egypt.

Email

mreda17@yahoo.com

City

-

Orcid

-

Volume

32

Article Issue

Issue 2-B

Related Issue

31930

Issue Date

2021-12-01

Receive Date

2021-09-05

Publish Date

2021-12-01

Page Start

23

Page End

31

Print ISSN

1110-2535

Online ISSN

2636-3305

Link

https://absb.journals.ekb.eg/article_204216.html

Detail API

https://absb.journals.ekb.eg/service?article_code=204216

Order

6

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

Monte carlo method estimates for internal dosimetry of well differentiated thyroid cancer patients

Details

Type

Article

Created At

22 Jan 2023