Diabetes is a syndrome of impaired carbohydrate, fat and protein metabolism caused by either lack of insulin secretion or decreased sensitivity of the tissues to insulin. Diabetes mellitus is the most common endocrine disease worldwide. Diabetes mellitus was induced by injection streptozotocin intraperitonealy at dose 47 mg/kg body mass. The present study was designed to investigate the possible therapeutic effects of Balanites aegyptiaca (Heglig dates) and Persea americana (Avocado fruit) water extracts on some hematological and biochemical parameters in streptozotocin diabetic rats at doses 100 mg/kg and 500 mg/kg body mass respectively for 30 days. Treatment extracts were given orally through a gavage tube. The current results revealed a significant decrease in RBCs, WBCs counts, Hb concentration, MCHC, serum total protein, albumin, insulin and C-peptide level in diabetic rats. On the other hand a significant increase was recorded in MCV value, serum glucose and Hb A1c level in diabetic group in comparison with the control group. Treatment with Balanites aegyptiaca, Persea americana revealed an improvements in these parameters.