The present work was designed to evaluate the protective role of date palm extract (DPE) as an antioxidant against toxicity induced with different doses; 1/5 LD50 and 1/10 LD50 of the methomyl. The changes in antioxidant parameters (SOD and CAT activities and GSH concentration) in addition to level of TBARS as an index of lipid peroxidation and NO concentration were investigated. In addition, the alteration in liver functions (ALAT, ASAT, ALP, TBIL,GGT, albumin, globulin and total proteins) was assessed. Also, some hematological parameters such as RBCs, WBCs count, lymphocyte, monocytes, neutrophils, platelets count, Hb concentration and HCT were measured. A patch of 42 male Wistar albino rats of average weight (125±5g) at the beginning of the experiment was divided into 7 main groups; I: control group, II:DPE group, rats were treated orally with DPE at a dose (1 g/k/day)for 2 weeks, III: DPE group, rats were treated orally with DPE at a dose (1 g/k/day) for 4 weeks. Methomyl groups; IV: rats were intoxicated with a 1/5LD50 for 2 weeks V: rats were intoxicated with a 1/10LD50for two weeks, VI: groups treated with DPE for two weeks as a protection before given DPE and methomyl1/5LD50for two weeks, VII: groups treated with DPE for two weeks as a protection before given DPE and methomyl 1/10LD50for two weeks. Each group contains 6 rats. The results showed a significant rise in TBARS, NO, ALAT, ASAT, ALP, GGT, and TBIL, while a significant reduction in some other parameters (CAT, SOD, GSH, Total protein, albumin).Significant decreases in some hematological parameters (RBCs, Hb, HCT and PLT, WBCs and lymphocytes) were reported. Also, the results showed a significant increase in neutrophils and eosinophils atin rats intoxicated with methomyl when compared to the control groups. The administration of the DPE ameliorated the deteriorative effects of the methomyl. In conclusion, the results obtained revealed that the administration of DPE had hepatoprotective effects against methomyl insulet in male Wistar albino rats by inhibiting oxidative stress through ROS scavenging activity and improvement of the biochemical markers.