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24327

UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Chemistry

Abstract

Enaminonitrile derivatives 1a,b were used as a versatile material for the synthesis of different heterocyclic compounds such as pyrazoloacetamide, pyrazolopyrimidinone, pyrazolobenzamide, pyrazolopyrimidines, pyrazolothiazinethiones, pyrazolopyrimidinedithiones, pyrazolocyanoacetamide, pyrazolopyrazoles, tetrazolopyrazoles, pyrazolotetrazolopyrimidines, and pyrazolotetrazolodiazepine derivatives, through the reaction with different electrophiles and nucleophiles. The newly synthesized compound were tested against gram positive and gram negative bacteria, fungi and two human tumor cell lines.

DOI

10.21608/absb.2016.24327

Keywords

pyrazolopyrimidine, pyrazolothiazinethiones, pyrazolotetrazolopyrimidines, pyrazolotetrazolodiazepine, Antimicrobial, Cytotoxic activity

Authors

First Name

Galal

Last Name

Sayed

MiddleName

H.

Affiliation

Departments of Organic Chemistry Lab., Chemistry, Faculty of Science, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Azab

MiddleName

E.

Affiliation

Departments of Organic Chemistry Lab., Chemistry, Faculty of Science, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Kurls

Last Name

Anwer

MiddleName

E.

Affiliation

Departments of Organic Chemistry Lab., Chemistry, Faculty of Science, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Nabil

Last Name

Negm

MiddleName

A.

Affiliation

Petrochemical, Egyptian Petroleum Research Institute

Email

-

City

-

Orcid

-

Volume

27

Article Issue

Issue 1-A

Related Issue

4488

Issue Date

2016-06-01

Receive Date

2016-02-01

Publish Date

2016-06-01

Page Start

9

Page End

22

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 27_Issue Issue 1-A_Pages 9-22.pdf

PDF . 512.4kB

Link

https://absb.journals.ekb.eg/article_24327.html

Detail API

https://absb.journals.ekb.eg/service?article_code=24327

Order

2

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT

Details

Type

Article

Created At

22 Jan 2023