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24326

SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 5-CINNAMOYLAMINO-2-CYANOMETHYL-1,3,4-THIADIAZOLE

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Last updated: 03 Jan 2025

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Chemistry

Abstract

Cinnamoyl isothiocyanate 1 was reacted with 2-cyanoethanoic acid hydrazide 2 to afford 1-cyanoacetyl-4-substituted thiosemicarbazide 3 which on treatment with a mixture of glacial acetic acid and acetic anhydride gave the desired 5-cinnamoylamino-2-cyanomethyl-1,3,4-thiadiazole 4. Compound 4 was subjected to react with aromatic aldehydes, phenylisothiocyanate, carbon disulphide and arylidene malononitrile to give coumarin 5, thiazolidines 8,9 and 1,3,4-thiadiazolo[3,2-a]pyridine 13 derivatives. The structures of all synthesized compounds were ascertained by spectral and analytical data.

DOI

10.21608/absb.2016.24326

Authors

First Name

Mahmoud

Last Name

Mahmoud

MiddleName

R.

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt.

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City

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Orcid

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First Name

Manal

Last Name

El-Shahawi

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt.

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City

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Orcid

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First Name

Fatma

Last Name

Abu El-Azm

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt.

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-

City

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Orcid

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First Name

Mohamed

Last Name

Abdeen

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt.

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City

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Orcid

-

Volume

27

Article Issue

Issue 1-A

Related Issue

4488

Issue Date

2016-06-01

Receive Date

2016-02-19

Publish Date

2016-06-01

Page Start

1

Page End

8

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 27_Issue Issue 1-A_Pages 1-8.pdf

PDF . 350.9kB

Link

https://absb.journals.ekb.eg/article_24326.html

Detail API

https://absb.journals.ekb.eg/service?article_code=24326

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Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 5-CINNAMOYLAMINO-2-CYANOMETHYL-1,3,4-THIADIAZOLE

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Article

Created At

22 Jan 2023