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11643

ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION OF TRACE CLOMIPRAMINE HYDROCHLORIDE AT CARBON PASTE ELECTRODE

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Last updated: 03 Jan 2025

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Abstract

A highly adsorptive stripping procedure for trace determination of the antidepressant drug Clomipramine hydrochloride was described. The drug was accumulated on a carbon paste electrode and a well-defined oxidation peak was obtained in acetate buffer pH 5.0.The method was based on controlled adsorptive accumulation of the drug for 150 sec. at a carbon electrode followed by voltammetric measurement of the surface species. By anodic adsorptive linear sweep (LSV) and differential pulse voltammetry (DPV), the voltammetric response at carbon paste electrode yields a linear calibration graph from  Clomipramine hydrochloride 4x10-9 to 2x10-8 mol L-1 and4x10-11 to 2x10-10 mol dm 3  for LSV and DPV , respectively. The voltammetric response is evaluated with respect to the pre-concentration potential and time, concentration dependence, detection limits, reproducibility and other variables. The method was applied for the determination of Clomipramine in diluted urine samples and in pharmaceutical preparations, the mean recovery was 101.06%. ANWAR A. WASSEL  

DOI

10.21608/absb.2006.11643

Keywords

Clomipramine hydrochloride, Carbon paste electrode, Stripping voltammetry, Differential Pulse Voltammetry, Pharmaceutical

Authors

First Name

ANWAR

Last Name

WASSEL

MiddleName

A.

Affiliation

National Organization for Drug Control and Research, P.O, 29, Cairo, Egypt .

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Orcid

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Volume

17

Article Issue

Issue 1-A

Related Issue

2157

Issue Date

2006-06-01

Receive Date

2018-08-26

Publish Date

2006-06-01

Page Start

103

Page End

111

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 17_Issue Issue 1-A_Pages 103-111.pdf

PDF . 292.2kB

Link

https://absb.journals.ekb.eg/article_11643.html

Detail API

https://absb.journals.ekb.eg/service?article_code=11643

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Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION OF TRACE CLOMIPRAMINE HYDROCHLORIDE AT CARBON PASTE ELECTRODE

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Article

Created At

22 Jan 2023