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11138

SYNTHESIS OF NOVEL PYRAZOLE, PYRIDAZINE AND PYRIMIDINE DERIVATIVES CONTAINING SULFONAMIDO MOIETY

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Chemistry

Abstract

Reaction of the hydrazone 2 with hydrazine hydrate, phenylhydrazine, benzoylhydrazine and/or semicarbazide in dioxane afforded the 3,5-diaminopyrazole derivatives 3-6, respectively. Refluxing 3 with acetic anhydride and/or benzoylchloride, furnished the N-acyl derivatives 7 and 8. On the other hand, fusion of 3 with different aromatic aldehydes produced the Schiff bases 9a-c, respectively. Treatment of 2 with urea, thiourea and/or guanidine hydrochloride furnished the pyrimidine and 1,3-thiazine derivatives 10-12, respectively. Reaction of 2 with ethyl cyanoacetate, ethyl acetoacetate, malononitrile and/or piperidine yielded the pyridazine derivatives 14 and 15, pyridopyridazine 17 and the enaminonitrile 18. Treatment of 18 with CS2 and/or phenylisothiocyanate produced 1,3-thiazine 20, dithioxopyrimidine 21 and the thiopyrimidine derivatives 22, respectively.

DOI

10.21608/absb.2007.11138

Keywords

Sulfonamide, Hydrazones, aminopyrazoles, pyrimidines, pyridazines

Authors

First Name

M.

Last Name

AZAB

MiddleName

-

Affiliation

Chemistry department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

EL-BOURDANY

MiddleName

A.

Affiliation

Chemistry department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

ABDEL-WAHAB

MiddleName

S.

Affiliation

Chemistry department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

SOLIMAN

MiddleName

A.

Affiliation

Chemistry department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

18

Article Issue

Issue 2-A

Related Issue

2115

Issue Date

2007-12-01

Receive Date

2007-09-15

Publish Date

2007-12-01

Page Start

167

Page End

178

Print ISSN

1110-2535

Online ISSN

2636-3305

Link

https://absb.journals.ekb.eg/article_11138.html

Detail API

https://absb.journals.ekb.eg/service?article_code=11138

Order

14

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

SYNTHESIS OF NOVEL PYRAZOLE, PYRIDAZINE AND PYRIMIDINE DERIVATIVES CONTAINING SULFONAMIDO MOIETY

Details

Type

Article

Created At

22 Jan 2023