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11124

SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS

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Last updated: 22 Jan 2023

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Tags

Chemistry

Abstract

Synthesis and reactions of  4-pyrazine-2-carboxamido carboxylic acid derivatives 3a-c were studied. Various N-[4-(5-oxo-oxazol-2-yl)-phenyl]pyrazine-2-carboxamides 7-11 were obtained via condensation of 3c with different chemical reagents. Interaction of 10b,c with p-toludine and/or hydrazine hydrate afforded the corresponding N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carboxamides 12a,b respectively. Antimicrobial screening showed that 3c possess a promising effect against the growth of Leuconostoc sp. and other tested Gram-positive, Gram-negative and fungi. Thestructures of the newly derivatives were confirmed by IR, 1H NMR, 13C NMR and mass spectra studies.

DOI

10.21608/absb.2007.11124

Keywords

4-pyrazine-2-carboxamido carboxylic acid derivatives, N-[4-(5-oxo-oxazol-2-yl)phenyl]pyrazine-2-carboxamides, N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carbox-amides, 1,2,4-triazine-6-one derivatives, Leuconostoc sp. Growth inhibitor

Authors

First Name

ASHRAF

Last Name

ABDELWAHAB

MiddleName

H.

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

Email

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City

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Orcid

-

First Name

A.

Last Name

EL-HADDAD

MiddleName

F.

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

F.

Last Name

EID

MiddleName

A.

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

A.

Last Name

BEDAIR

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

A.

Last Name

ADAWY EL-DEEB

MiddleName

M.

Affiliation

Department of Research abd Development Affair Sugar & Integrated Industries Companies, EL-Hwamdia, Giza

Email

-

City

-

Orcid

-

First Name

G.

Last Name

EL-SHERBENY

MiddleName

M.

Affiliation

Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

18

Article Issue

Issue 2-A

Related Issue

2115

Issue Date

2007-12-01

Receive Date

2007-09-15

Publish Date

2007-12-01

Page Start

127

Page End

140

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 18_Issue Issue 2-A_Pages 127-140.pdf

PDF . 293.3kB

Link

https://absb.journals.ekb.eg/article_11124.html

Detail API

https://absb.journals.ekb.eg/service?article_code=11124

Order

9

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

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Article

Created At

22 Jan 2023