Beta
ManageSearchChatDiscover
10871

NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Chemistry

Abstract

Treatment of N-aryl 2-chloroacetamides (2a-f) with sodium isopropoxide in isopropyl alcohol afforded 1,4-diarylppiperazine-2,5-dione (3a-f). Treatment of malononitrile dimer (9), ethyl cyanoacetate (11) and the arylidines of cyanothioacetamide (13) with DMFDMA afforded the corresponding enamines (10, 12 and 14) respectively. Reaction of 14 with either sodium ethoxide or sodium methoxide affords 5-cyano-4-ethoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (15) and  5-cyano-4-methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (16) respectively.

DOI

10.21608/absb.2007.10871

Keywords

1,4-DIARYLPIPERAZINE-2,5-DIONE, 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE

Authors

First Name

FATHI

Last Name

ABU-SHANAB

MiddleName

A.

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University, Assiut 71524,

Email

-

City

-

Orcid

-

Volume

18

Article Issue

Issue 1-A

Related Issue

2097

Issue Date

2007-06-01

Receive Date

2007-07-02

Publish Date

2007-06-01

Page Start

151

Page End

161

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 18_Issue Issue 1-A_Pages 151-161.pdf

PDF . 319.2kB

Link

https://absb.journals.ekb.eg/article_10871.html

Detail API

https://absb.journals.ekb.eg/service?article_code=10871

Order

2

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023