Aluminium (AL) is an important element with known toxicity in human body, mainly in the centeral nervous system. Melatonin is known as antioxidant, free radical scaverger and metal chelator. The aim of this study to determine the effect of oral administration of melatonin on accumulation and toxicity of Alclз in brain of ovariectomized female rats. Orally administerated of Alcl3 at dose (10mg/Kg b.w.) for 8 weeks showed significant decrease in total protein,acetylcholenesterase(AchE) and glutathione content in brain tissues. While the lipid peroxidation Lpo, triglycerides Trig, total cholesterol  and phospholipids showed significant Increase. The treatment with melatonin at dose (5mg/kgb.w.) for 8 weeks showed slightly decreased pervious parameters.These data indicated that  orally treatment with melatonin against Alcl3 is probably responsible for preventaion of oxidative damage and Al-toxicity induced injury to brain of  experimental rats.