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BETA CAROTENE AND HESPERIDIN ANTIOXIDANTS MITIGATE HEPATOTOXIC EFFECTS OF IMIDACLOPRID IN MALE RATS.

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Last updated: 03 Jan 2025

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Botany
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Zoology

Abstract

The role of beta carotene (20mg/kg) and hesperidin (100mg/kg) in protection against imidacloprid (45 mg/kg, 90 mg/kg that represent 1/10 LD50 and 1/5 LD50 of IM) induced hepatotoxicity wasinvestigated. All the treatments were given orally and daily for thirty days.
The treatment of rats with IM showed a significant increase in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Gamma-glutamyltransferase (GGT), alpha fetoprotein (α-FP), total bilirubin, total cholesterol (TC) and triglycerides (TG). Also, Imidacloprid treatment led to a significant rise of hepatic malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α) and nitric oxide (N.O). On the other-hand, plasma total protein (TP) and albumin tended to a significant decrease due to IM treatment. Hepatic catalase, reduced glutathione (GSH) and superoxide dismutase (SOD) of IM group exhibited a significant decrease. The histological study showed lesions in the liver of treated rats with IM. Both beta carotene and hesperidin mitigate the deleterious effects of IM on previous parameters as manifested by a significant decrease of MDA, N.O, liver enzymes, and improved antioxidant enzyme levels and liver histology. The protective effect of beta carotene and hesperidin in combination is more pronounced. Therefore, our results clarify the synergistic effect of these two antioxidants on alleviating imidacloprid toxicity.

DOI

10.21608/absb.2017.8164

Keywords

Imidacloprid, beta, carotene, Hesperidin, liver function, Oxidative Stress, Synergistic effect, hepatoprotection

Authors

First Name

S.

Last Name

Bashandy

MiddleName

A.

Affiliation

Department of Pharmacology, Medical Division, National Research Centre, Cairo, Egypt.

Email

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City

-

Orcid

-

First Name

M.

Last Name

Bashandy,

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Al -Azhar University, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

El Zawahry

MiddleName

I.

Affiliation

Zoology Department, Faculty of Science, Al -Azhar University, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Abdel Naby

MiddleName

F.

Affiliation

Zoology Department, Faculty of Science, Al -Azhar University, Egypt

Email

-

City

-

Orcid

-

First Name

F.

Last Name

Adly

MiddleName

-

Affiliation

Pathology Department, National Research Center, Egypt.

Email

-

City

-

Orcid

-

Volume

28

Article Issue

Issue 1-C

Related Issue

1592

Issue Date

2017-06-01

Receive Date

2017-01-08

Publish Date

2017-06-10

Page Start

15

Page End

27

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 28_Issue Issue 1-C_Pages 15-27.pdf

PDF . 802.9kB

Link

https://absb.journals.ekb.eg/article_8164.html

Detail API

https://absb.journals.ekb.eg/service?article_code=8164

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Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

BETA CAROTENE AND HESPERIDIN ANTIOXIDANTS MITIGATE HEPATOTOXIC EFFECTS OF IMIDACLOPRID IN MALE RATS.

Details

Type

Article

Created At

22 Jan 2023