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7559

EVALUATION OF IMMUNE RESPONSES IN CHILDREN INFECTED WITH ENTAMOEBA HISTOLYTICA AFTER TREATMENT WITH METRONIDAZOLE

Article

Last updated: 03 Jan 2025

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Botany
Microbiology
Zoology

Abstract

This study was designed to evaluate the immune responses in children infected with E. histolytica after treatment with metronidazole. Immunological evaluation was performed by measurement of secreted cytokines (interleukin, IL-10-tumor necrosis factor-α in blood of children, on the other hand E. histolytica cyst output in children stool was measured. The present investigation is directed to study the therapeutic effect of different doses of metronidazole a treatment known for controlling of E. histolyticainfection in children. The children infected with E. histolytica were divided into three group according to the dose of metronidazole(Flagyl syrup). The 1st, second and third group were treated with 30, 25 and 15 mg /kg per day for 7 days, in 3 doses respectively. The results of the present study revealed a significant reduction in cyst count in stool of children treated by metronidazole at dose of 30 mg /kg in comparison with control un treated. The data also revealed that serum IL-10 and TNF-alpha were significantly increased as an immunological response for children treated with metronidazole at dose of 30 mg/kg body weight in comparison with children of dose 15 mg and untreated control group. Also the NO level revealed significant decrease in children at dose 30 mg / kg in comparison with 25 and 15 mg/kg group.

DOI

10.21608/absb.2009.7559

Keywords

IL10, TNF-alpha, NO, Metronidazole

Authors

First Name

ADHAM

Last Name

SADIQ

MiddleName

G.

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

Email

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City

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Orcid

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Volume

20

Article Issue

Issue 2-C

Related Issue

1452

Issue Date

2009-12-01

Receive Date

2009-06-09

Publish Date

2009-12-01

Page Start

45

Page End

58

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 20_Issue Issue 2-C_Pages 45-58.pdf

PDF . 151.9kB

Link

https://absb.journals.ekb.eg/article_7559.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7559

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4

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

EVALUATION OF IMMUNE RESPONSES IN CHILDREN INFECTED WITH ENTAMOEBA HISTOLYTICA AFTER TREATMENT WITH METRONIDAZOLE

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Type

Article

Created At

22 Jan 2023