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7550

SYNTHESIS OF SOME NOVEL THIAZOLE, THIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES CONTAINING TOSYL MOIETY

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Last updated: 22 Jan 2023

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Chemistry

Abstract

Interaction of 4-aminoacetophenone (1) with p-tolyl sulphonamide afforded 1-[4-tosyl amino) phenyl]ethanone (2). Treatment of 2 with bromine water yielded 2-bromo-1-[4-tosyl amino) phenyl]ethanone (3), which reacted with thiourea to give 2-amino thiazole derivative (4). Compound 2 was condensed with phenyl acetaldehyde and malononitrile to give derivatives (5) and (7), which were respectively reacted with o-aminothiophenol and carbon disulfide to give derivatives (6) and (9). Reaction of 7 under Gewald reaction condition afforded the thiophen-3-carbonitrile derivative (11) which consequently reacted with 4-fluorobenzylidinemalononitrile, phenyl isothiocyanate to give compounds 12 and 15, respectively. The structures of these compounds were confirmed by infrared, mass and 1H-NMR spectra. The measurement of potential cytotoxicity for the compound 11 was tested and has exhibit anticancer of liver and breast.

DOI

10.21608/absb.2009.7550

Keywords

thiazole, THIOPHENE, THIENOPYRIDINE, THIENOPYRIMIDINE TOSYL MOIETY

Authors

First Name

S.

Last Name

HESSIEN

MiddleName

A.

Affiliation

Chemistry Department, Faculty of Science (girls), Al -Azhar University, Cairo, Egypt.

Email

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Orcid

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First Name

MONA

Last Name

KADAH

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science (girls), Al -Azhar University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

N.

Last Name

MARZOUK

MiddleName

A.

Affiliation

Chemistry Department, Faculty of Science (girls), Al -Azhar University, Cairo, Egypt.

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-

City

-

Orcid

-

Volume

20

Article Issue

Issue 1-A

Related Issue

1450

Issue Date

2009-06-01

Receive Date

2009-01-09

Publish Date

2009-06-01

Page Start

139

Page End

160

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 20_Issue Issue 1-A_Pages 139-160.pdf

PDF . 600.3kB

Link

https://absb.journals.ekb.eg/article_7550.html

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https://absb.journals.ekb.eg/service?article_code=7550

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12

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

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Article

Created At

22 Jan 2023