Beta
ManageSearchChatDiscover
7549

SYNTHESIS OF SOME BENZOFURANYL THIENO[2,3-D] PYRIMIDINE DERIVATIVES WITH BIOLOGICAL INTEREST

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Chemistry

Abstract

Interaction of visnaginone or khellinone (1a,b) with cyanoacetamide, ethyl cyanoacetate or molanonitrile and elemental sulfur in presence of triethylamine afforded thiophene enamino derivatives (2a-d) respectively according to Gewald method. Acetylation of 2a with acetic anhydride gave 3. Condensation of 2b with p-chlorobenzaldehyde yielded 4. Compound 6 was afforded from reaction of enamino carboxamide (2b) with thiourea.. Compound 2b reacted with benzoyl chloride to give thienopyrimidine (8). N-phenyl thienopyrimidine (11) and N-amino thienopyrimidine (13) were prepared from reaction of 2c with phenyl isothiocyanate and hydrazinolysis of 12 with hydrazine hydrate. The structures of these compounds were confirmed by infrared, mass and 1H-NMR spectra. The biological activity of some compounds were discussed and found to be active.

DOI

10.21608/absb.2009.7549

Keywords

BENZOFURANYL THIENO[2,3-D], pyrimidine derivatives

Authors

First Name

NADIA

Last Name

TAHA

MiddleName

M.

Affiliation

Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

ENAS

Last Name

ISLAM

MiddleName

-

Affiliation

Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

NERMIN

Last Name

MARZOK

MiddleName

A.

Affiliation

Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

ABEER

Last Name

ELATRASH

MiddleName

M.

Affiliation

Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

JEHANE

Last Name

MICKY

MiddleName

A.

Affiliation

Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

20

Article Issue

Issue 1-A

Related Issue

1450

Issue Date

2009-06-01

Receive Date

2009-02-08

Publish Date

2009-06-01

Page Start

125

Page End

138

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 20_Issue Issue 1-A_Pages 125-138.pdf

PDF . 124.1kB

Link

https://absb.journals.ekb.eg/article_7549.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7549

Order

11

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023