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Part 1: SYNTHESIS AND REACTIONS OF SOME NEW PYRAZOLO[4,5-D]IMIDAZOLE DERIVATIVES AND SCREENING THEIR ANTIBACTERIAL AND ANTITUMOR ACTIVITIES

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Last updated: 22 Jan 2023

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Chemistry

Abstract

Reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with diazotized aromatic amines gave the corresponding diazenyl derivatives 1, which were condensed with carbonyl compounds to give the arylidene derivatives 2. Reaction of the parent pyrazolone with urea, thiourea and guanidine gave the pyrazoloimidazole derivatives 3. compound 3a reacted with thiourea in DMF to give the thiourea derivative 4. The reaction of 4 with malonic acid and acetyl chloride gave the pyrimidinedione derivative 5, which on reaction with thiourea in presence of sodium ethoxide gave the triazine derivative 6. S-alkylation of 6 with ethyl chloroacetate gave the ethyl acetate derivative 7, which on hydrolysis gave the corresponding acid, derivative8 and on reaction with hydrazine hydrate gave the corresponding acetohydrazide 9. the reaction of compound 9 with salicylaldehyde gave the pynazolidinone 10, while with carbon disulphide in alkaline solution it gave the oxadiazole thione 11 respectively. Some of the new compounds showed antimicrobial and antitumor activities.

DOI

10.21608/absb.2009.7546

Keywords

Pyrazoloimidazole, pyrimidinedione, triazine, Antimicrobial, antitumor

Authors

First Name

NAHED

Last Name

ABD EL-GHAFFAR

MiddleName

F.

Affiliation

Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.

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Orcid

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First Name

MONA

Last Name

KADAH

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.

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-

City

-

Orcid

-

First Name

AZZA

Last Name

RADWAN

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.

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-

City

-

Orcid

-

First Name

SARA

Last Name

ABD EL-AL

MiddleName

N.

Affiliation

Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.

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-

City

-

Orcid

-

First Name

ASMAA

Last Name

SALMAN

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.

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Volume

20

Article Issue

Issue 1-A

Related Issue

1450

Issue Date

2009-06-01

Receive Date

2009-01-09

Publish Date

2009-06-01

Page Start

91

Page End

101

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 20_Issue Issue 1-A_Pages 91-101.pdf

PDF . 136.7kB

Link

https://absb.journals.ekb.eg/article_7546.html

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https://absb.journals.ekb.eg/service?article_code=7546

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8

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Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

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Article

Created At

22 Jan 2023