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7380

RP HPLC DETERMINATION OF BENZHEXOL HYDROCHLORIDE IN TABLET FORMULATIONS AND URINE

Article

Last updated: 03 Jan 2025

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Tags

Chemistry

Abstract

A new, rapid and sensitive reverse phase HPLC method was developed and validated for the determination of benzhexol hydrochloride in tablet formulations and urine. The mobile phase used is acetonitrile and water, ( 50 % v/v ) and the pH was adjusted to 5 using phosphoric acid. The separation was achieved on C18 reversed-phase column (250 mm x 4 mm i.d.). The flow rate was 0.6 ml/min and UV detection is at 254nm. The retention time for benzhexol hydrochloride was 7.4 min. The calibration curve was linear up to 40 µg/mL. The mean recovery for benzhexol hydrochloride is 101.16. The assay was precise within day and between days. The method provided excellent sensitivity, recovery, accuracy and reproducibility in therapeutic or toxic concentrations. Common excipients do not interfere.

DOI

10.21608/absb.2010.7380

Keywords

Benzhexol hydrochloride, Reverse phase HPLC, C18 reversed-phase column

Authors

First Name

RABIE

Last Name

FARAG

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Al -Azhar University, Cairo, Egypt.

Email

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City

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Orcid

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First Name

SABAH

Last Name

MOLTAZRM

MiddleName

M.

Affiliation

El-Baha University, El-Baha, Soudi Arabia

Email

-

City

-

Orcid

-

First Name

ASHRAF

Last Name

AHMED

MiddleName

M.

Affiliation

Forensic chemist, Medico-Legal Organization, Ministry of Justice

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-

City

-

Orcid

-

Volume

21

Article Issue

Issue 2-A

Related Issue

1401

Issue Date

2010-12-01

Receive Date

2010-08-20

Publish Date

2010-12-01

Page Start

267

Page End

274

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 21_Issue Issue 2-A_Pages 267-274.pdf

PDF . 516.4kB

Link

https://absb.journals.ekb.eg/article_7380.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7380

Order

19

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

RP HPLC DETERMINATION OF BENZHEXOL HYDROCHLORIDE IN TABLET FORMULATIONS AND URINE

Details

Type

Article

Created At

22 Jan 2023