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7378

SYNTHESIS OF A NEW SERIES OF AMINO ACID DERIVATIVES OF SUBSTITIUTED COUMARIN AND ITS ANTIMICROBIAL ACTIVITY APPLICATIONS

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Last updated: 03 Jan 2025

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Tags

Chemistry

Abstract

A series of new substituted coumarin amino acid derivatives have been synthesized, characterized and screened for their (In Vitro) antimicrobial activity against Gram-positive and Gram-negative bacteria as well as for their antifungal activity and (In Vivo) application against plant pathogenic fungus, Fusarium oxysporium the causal agent of beans (Phaseolus vulgaris .L.), plant wilt disease Interestingly, our results show available antimicrobial response of the newly substituted coumarins in two main aspects firstly, (in vitro) the inhibition potential and the types of the effective coumarins compounds tested were more upon the filamentous plant pathogenic fungi than on both Gram positive and Gram-negative bacteria tested ,this may give an indication that the mechanism of the inhibition that exerted upon filamentous fungi as Eukaryotic representative class is completely different from that upon bacteria as Prokaryotic representative class .Secondary,.( In Vivo), some of thenewly substituted coumarins can successfully inhibit the growth of plant pathogenic fungus as Fusarium oxysporium in a different degrees.

DOI

10.21608/absb.2010.7378

Keywords

Coumarin, Amino acids, antimicrobial activity, plant pathogenic fungi, Fusarium wilt disease, Beans Plants (Phaseolus. Vulgaris L.)

Authors

First Name

M.

Last Name

ZAHER

MiddleName

R.

Affiliation

Chemistry Department, Faculty of Science, Al -Azhar University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

A.

Last Name

EL-AGRODY

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Al -Azhar University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

H.

Last Name

HASSAN

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Al -Azhar University, Cairo, Egypt.

Email

hassanomar61@gmail.com

City

-

Orcid

-

First Name

A.

Last Name

FARRAG

MiddleName

A.

Affiliation

Department of Botany, Faculty of Science, Al-Azhar University ,Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

21

Article Issue

Issue 2-A

Related Issue

1401

Issue Date

2010-12-01

Receive Date

2010-08-05

Publish Date

2010-12-01

Page Start

239

Page End

250

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 21_Issue Issue 2-A_Pages 239-250.pdf

PDF . 185.4kB

Link

https://absb.journals.ekb.eg/article_7378.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7378

Order

17

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

SYNTHESIS OF A NEW SERIES OF AMINO ACID DERIVATIVES OF SUBSTITIUTED COUMARIN AND ITS ANTIMICROBIAL ACTIVITY APPLICATIONS

Details

Type

Article

Created At

22 Jan 2023