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7361

CHLOROACETONITRILE IN HETERO CYCLIC SYNTHESIS; NOVEL ROUTE FOR THE SYNTHESIS OF THIAZOLIDINE, CHORMENE, PYRROLE, AND PYRAZOLE DERIVATIVES AS ANTIMICROBIAL AGENTS

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Chemistry

Abstract

Thiazolidinone (5b), chormeno [2,3-b] pyrrole (11) and 2-(2-ethoxyphenylamino) acetonitrile (16), were obtained from the reaction of chloroacetonitrile (1) with thioglycollic acid (2) , salicyaldehyde in presence of malononitrile, and o-phentidine ,respectively. Fusion of compound (5b) with hydrazine hydrate furnished (6), while fusion chloroacetonitrile (1), 2-chlorobenzaldehyde and thioglycollic acid (2) gave (8). Treatment of (1), and (16) with a mixture of aromatic aldehyde and hydrazine hydrate gave the corresponding Pyrazole derivatives (18,24,and 25). The reaction of compound (11) with each of acetic anhydride, carbon disulphide, and formic acid gave the corresponding chormeno [2,3-b] pyrrole derivatives(13-15),respectively. Refluxing (16) with salicyaldehyde in presence of ammonium acetate afforded- N-(2-ethoxyphenyl)-2-imino-2H-chromen -3-amine (19) .The novel pyrrole derivative (20) was obtained through reaction of (16) with a mixture of 2-chlorobenzaldehyde and malononitrile.

DOI

10.21608/absb.2010.7361

Keywords

thiazolidine, chormene, pyrazole derivatives

Authors

First Name

GAMEEL

Last Name

EL-HAG-ALI

MiddleName

A.

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt

Email

elhag1970@yahoo.com

City

-

Orcid

-

Volume

21

Article Issue

Issue 2-A

Related Issue

1401

Issue Date

2010-12-01

Receive Date

2010-01-04

Publish Date

2010-12-01

Page Start

15

Page End

26

Print ISSN

1110-2535

Online ISSN

2636-3305

Link

https://absb.journals.ekb.eg/article_7361.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7361

Order

2

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023