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7359

SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE, THIAZOLO[3,2-A]PYRIDINE AND THIAZOLO[3,2-A]-1,8-NAPHTHYRIDINE DERIVATIVES CONTAINING MORPHOLINE MOIETY

Article

Last updated: 22 Jan 2023

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Chemistry

Abstract

One pot reaction of morpholin or piperidine , ethyl cyanoactate,and thioglycollic acid afforded the novel 2-(2-morpholino-2-oxo-ethylidene)-4-thiazolidinone and 2-(2-oxo-2-(piperidin-1-yl) ethylidene) thiazolidin-4-one (1a,b).Cyclization of (1a) with chloroacetonitrile and malononitrile afforded the novel thiazolidinone derivatives (2a,b).Refluxing of (1a) with o-chlorobenzaldehyde,and chloroacetonitrile furnished (3). Compound (1a) reactedwith aromatic aldehydes in refluxing ethanol affording 5-arylmethylidine-4-thiazolidinone (4a,b).4-Thiazolidinone derivative (4a) was cond-ensed with hydrazine hydrate to give (5). Thiazolo [3,2-a]pyridine and pyrano [2,3-d]thiazole derivatives (6,7) were produced through reaction of (4a,b,) witha mixture aromatic aldehyde and malononitrile. Compound (6) was reacted with ethyl isot-hiocynate and hydrazine hydrate to give the corresponding thiazolopyridine derivatives (8,9) .When compound (6) was treated with each of HCOOH, C6H5CO Cl,,and CS2 and malononitrile , the novel thiazolo [3,2-a]-1,8-naphthyridine derivati -ves (10-13) were obtained.

DOI

10.21608/absb.2010.7359

Keywords

Thiazolo[3,2-a] pyridine, thiazolo[4,5-c] pyrazole, and thiazolo[3,2-a]-1,8-naphtharyidine derivatives

Authors

First Name

GAMEEL

Last Name

EL-HAG-ALI

MiddleName

A.

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt

Email

elhag1970@yahoo.com

City

-

Orcid

-

Volume

21

Article Issue

Issue 2-A

Related Issue

1401

Issue Date

2010-12-01

Receive Date

2010-02-02

Publish Date

2010-12-01

Page Start

1

Page End

14

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 21_Issue Issue 2-A_Pages 1-14.pdf

PDF . 155.1kB

Link

https://absb.journals.ekb.eg/article_7359.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7359

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Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

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Article

Created At

22 Jan 2023