Beta
ManageSearchChatDiscover
7332

UTILITY OF THIOGLYCOLLIC ACID IN THE SYNTHESIS OF SOME NEWLY THIAZOLIDINONE AND THIAZOLO[3,2-A]PYRIDINE DERIVA-TIVES AS ANTIMICROBIAL AGENTS

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Chemistry

Abstract

A series of thiazolo[3,2-a] pyridine derivatives 3, 4a-d, 9a-e, 11a-e, and 13 were synthesized through the interaction of 4,5-dihydro-2-ethoxycarbonyl methyllidine-4-thiaz-olidinone 1 with the corresponding α,β-unsaturated nitrile compounds 2a-e, 6a-e, 10a-e,and 12, respectively.4-Thiazolidinone derivative 1 was reacted with 2 moles of p-chlorobenza-ldehyde to give 14 which was reacted with malononitrile to afford the corresponding thiazolo [3,2-a]pyridine derivative 15. Acetylation of compound 15 with acetic anhydride furnished N-acetyl amino derivative 16. The structures of these compounds were elucidated on the basis of their spectral data (IR, 1HNMR and MS).These compounds were also screened for their antimicrobial activity against pseudomonas aeruginosa, Bacillus subtilis, Penicillium italicum and Syncephalas trumracemosum by using paper disc diffusion method using Chloroamphenicoland Terbifinas standard drugs.

DOI

10.21608/absb.2010.7332

Keywords

4-thiazolidinone, Thiazolo [3,2-a] pyridines, antimicrobial activity

Authors

First Name

GAMEEL

Last Name

ELHAGALI

MiddleName

A.

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

HESSEN

Last Name

EL-TAMAMAY

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Sebha University, Sebha, Libya

Email

-

City

-

Orcid

-

First Name

MA-NSOUR

Last Name

EL-SENUSSI

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Sebha University, Sebha, Libya

Email

-

City

-

Orcid

-

First Name

ZAMZAM

Last Name

ELBASHER

MiddleName

ALI

Affiliation

Department of Chemistry, Faculty of Science, Sebha University, Sebha, Libya

Email

-

City

-

Orcid

-

Volume

21

Article Issue

Issue 1-A

Related Issue

1398

Issue Date

2010-06-01

Receive Date

2010-01-02

Publish Date

2010-06-01

Page Start

175

Page End

188

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 21_Issue Issue 1-A_Pages 175-188.pdf

PDF . 196.9kB

Link

https://absb.journals.ekb.eg/article_7332.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7332

Order

12

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023