Beta
ManageSearchChatDiscover
7196

SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FEXONFENDINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Chemistry

Abstract

Spectrophotometric method have been developed for the assay of Fexonfendine hydrochloride (FEX) in pure and pharmaceutical formulations. This method is based on the formation of chloroform soluble ion-association complexes of (FEX) with picric acid(PIC), bromphenol blue (BPB) and with chlorophenol red (CPR) with absorption maximum at 403 nm , at 429 nm and 418 nm for PIC ,BPB and CPR, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increasing in concentration of FEX,. Effect of the extracting solvents, effect of pH and effect of temperature on the stability of ion-associates have been investigated for studying the ion-assosciates of the cited drugs with the reagents under consideration

DOI

10.21608/absb.2011.7196

Keywords

Spectrophotometric determination, Fexonfendine hydrochloride

Authors

First Name

M.

Last Name

ELNAWAWY

MiddleName

-

Affiliation

Chemistry Department , Faculty of Science, Al-Azhar University, Cairo , Egypt.

Email

-

City

-

Orcid

-

First Name

RABIE

Last Name

FARAG

MiddleName

S.

Affiliation

Chemistry Department , Faculty of Science, Al-Azhar University, Cairo , Egypt.

Email

-

City

-

Orcid

-

First Name

YASSER

Last Name

ABD ELKADER

MiddleName

A.

Affiliation

Medico-Legal Department, Ministry of Justice, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

ADAWAY

MiddleName

M.

Affiliation

Medico-Legal Department, Ministry of Justice, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

S.

Last Name

AL-SALAM

MiddleName

R.

Affiliation

Medico-Legal Department, Ministry of Justice, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

23

Article Issue

Issue 1-A

Related Issue

1367

Issue Date

2012-06-01

Receive Date

2012-01-02

Publish Date

2012-06-01

Page Start

13

Page End

21

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 23_Issue Issue 1-A_Pages 13-21.pdf

PDF . 605.3kB

Link

https://absb.journals.ekb.eg/article_7196.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7196

Order

2

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023