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TWO SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GRISEOFULVIN IN TABLETS

Article

Last updated: 03 Jan 2025

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Tags

Chemistry

Abstract

Two simple and rapid spectrophotometric methods have been described for the assay of griseofulvin (GRF) either in pure form or in pharmaceutical formulations. The first method (A) is based on charge transfer complex reaction using 7,7,8,8-tetracyanoquinodimethane (TCNQ). The complex showed absorbance maximum at 842 nm. Beer's law is obeyed over the concentration range of 5–200 μg mL−1. The second method (B) is based on the formation of coloured ethylenechloride extractable ion-association complex of GRF with Mo(V)-thiocyanate with absorption maximum at 470 nm. Beer’s law is obeyed in the concentration range of 2-150 μg mL-1. The proposed methods were applied successfully to the determination of the examined drug either in a pure or pharmaceutical dosage forms. No interference was observed from common excipients present in pharmaceutical formulations.

DOI

10.21608/absb.2011.7188

Keywords

Griseofulvin, TCNQ, ion-pair formation reaction, Tablets

Authors

First Name

EMAN

Last Name

FRAG

MiddleName

Y.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.

Email

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City

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Orcid

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First Name

AHMED

Last Name

MOHAMED

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.

Email

-

City

-

Orcid

-

First Name

GEHAD

Last Name

MOHAMED

MiddleName

G.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.

Email

-

City

-

Orcid

-

First Name

EBTESAM

Last Name

ALRAHMONY

MiddleName

E.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.

Email

-

City

-

Orcid

-

Volume

22

Article Issue

Issue 1-A

Related Issue

1363

Issue Date

2011-06-01

Receive Date

2011-02-03

Publish Date

2011-06-01

Page Start

187

Page End

202

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 22_Issue Issue 1-A_Pages 187-202.pdf

PDF . 891.1kB

Link

https://absb.journals.ekb.eg/article_7188.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7188

Order

13

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

TWO SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GRISEOFULVIN IN TABLETS

Details

Type

Article

Created At

22 Jan 2023