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7185

SOME CYCLIZATION REACTIONS WITH 2-(4-OXOTHIAZOLIDIN-2-YLIDENE) ACETONITRILE WITH Α-Β UNSATURATED NITRILE COMPOUNDS

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Last updated: 03 Jan 2025

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Chemistry

Abstract

A novel 2- Cyanomethine- 4,5dihydro-4-oxo-5-(2,4dichlorophenyl) methylidine 1,3 thiazole (2) was obtained via the reaction of 4-thiazolidinone (1) with 2,4 dichloro- benzaldehyde .Treatment of 4-thiazolodinone derivatives(2) with 2,4 dichlorobe-nzaldhyde afforded 2,5-bis arylmethylidine derivatives (3a-d). Cyclization of compound (2) with various α-Cyanocinnamonitriles(4a-c) afforded the corresponding thiazolopyrid-ine enaminonitrile derivatives (5a-c). Reaction of compound (2) with α-ethoxycarbonyl cinnamonitriles (7a-c) gave the corresponding thiazolo[3,2-a]pyridine enaminoester deri-vatives (10a-c) . Also α-formamidocinnamonitriles (11a-c) were reacted with compound (2) and gave thiazolo [3,2-a] pyridine derivatives (12a-c). The reaction of (5a) with hydrazine hydrate, carbon disulphide in pyridine and malononitrile afforded the corres-pondding thiazolo pyridine and thiazolonaphthyridine derivatives (15),(16) and (17); respectively.

DOI

10.21608/absb.2011.7185

Keywords

5-Arylmethylidine-4-thiazolinones, thiazolo[3,2-a] pyridines, thiazo-lonaphtjyridine

Authors

First Name

SHABAN.

Last Name

MOHAMED

MiddleName

I.

Affiliation

Technology Engineering Institute, Tamoh, Giza, Egypt.

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Volume

22

Article Issue

Issue 1-A

Related Issue

1363

Issue Date

2011-06-01

Receive Date

2011-02-08

Publish Date

2011-06-01

Page Start

141

Page End

154

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 22_Issue Issue 1-A_Pages 141-154.pdf

PDF . 150.2kB

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https://absb.journals.ekb.eg/article_7185.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7185

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Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

SOME CYCLIZATION REACTIONS WITH 2-(4-OXOTHIAZOLIDIN-2-YLIDENE) ACETONITRILE WITH Α-Β UNSATURATED NITRILE COMPOUNDS

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Article

Created At

22 Jan 2023