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BIS-ISOTHIOCYANATES IN HETEROCYCLIC SYNTHESIS: SYNTHESIS OF BIS 4-THIAZOLIDINONES, BIS THIAZOLES, AND BIS 4-AMINO-THIAZOLE DERIVATIVES

Article

Last updated: 03 Jan 2025

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Chemistry

Abstract

Bis 2-thioxo-4-thiazolidinones (5a,b) were achieved by cyclocondensation of bis-isothiocyanates (3a,b) with sulfanylacetic acid at reflux temperature. Compounds (5a-c) were exploited to synthesize the versatile hitherto unknown bis(2-thioxo-4-thiazolidinone) deriva-tives (8, 9, 11, 12 & 16) via its reaction with some electrophiles. Reaction of bis ammonium dithiocarbamate derivatives [2b, (2a,c)] with chloroacetone, 4-nitrophenacyl bromide and 3-(2-bromoacetyl)-2H-chromene-2-one gave the corresponding bis thiazoles [18, (23a,b), 24], respectively, whereas, reaction of 2a,b with chloroacetonitrile gives bis (4-aminothiazoles) 21a,b. The synthesized compounds were characterized by IR, 1HNMR and mass spectral studies.

DOI

10.21608/absb.2011.7177

Keywords

Bis-isothiocyanates, bis 4-thiazolidinones, bis thiazoles, bis 4-aminothiazole derivatives

Authors

First Name

HAMDY

Last Name

THABET

MiddleName

KH.

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt.

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Volume

22

Article Issue

Issue 1-A

Related Issue

1363

Issue Date

2011-06-01

Receive Date

2011-01-01

Publish Date

2011-06-01

Page Start

69

Page End

84

Print ISSN

1110-2535

Online ISSN

2636-3305

Link

https://absb.journals.ekb.eg/article_7177.html

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https://absb.journals.ekb.eg/service?article_code=7177

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5

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

BIS-ISOTHIOCYANATES IN HETEROCYCLIC SYNTHESIS: SYNTHESIS OF BIS 4-THIAZOLIDINONES, BIS THIAZOLES, AND BIS 4-AMINO-THIAZOLE DERIVATIVES

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Article

Created At

22 Jan 2023