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UTILITY OF SOME SULPHA DRUGS IN SYNTHESIS OF NEW BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS : SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL THIOSEMICARBAZIDE DERIVATIVES

Article

Last updated: 03 Jan 2025

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Tags

Chemistry

Abstract

N-(4-(N-(2,6-dimethoxypyrimidin-4-yl)sulfamoyl)phenyl) hydrazine carbothioamide novel thiosemicarbazide (3) was used as starting material for synthesis of some novel Diacetyl hydrazine-carbothioamide (4), 1,3,4-Thiadiazol (7), 1,2-bis(carbothioamide) (9), 3,5-di-oxopyrazolidine (10), oxo-4,5-dihydropyrazole (11), 3,4-dihy-drophthalazine (15) and 3,6-dioxopiperazine (16).Where we found that, 1,2-bis(carbothioamide) (5), 1,2,4-triazole (6), carbamothioyl formohydrazonate (8) have anticancer activity of drug (s) using (E.A.C).

DOI

10.21608/absb.2011.7175

Keywords

SULPHA DRUGS, THIOSEMICARBAZIDE DERIVATIVES

Authors

First Name

E.

Last Name

AHMED

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.

Email

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City

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Orcid

-

First Name

N.

Last Name

TAHA

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

N.

Last Name

NADY

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.

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-

City

-

Orcid

-

Volume

22

Article Issue

Issue 1-A

Related Issue

1363

Issue Date

2011-06-01

Receive Date

2011-01-03

Publish Date

2011-06-01

Page Start

57

Page End

68

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 22_Issue Issue 1-A_Pages 57-68.pdf

PDF . 149.3kB

Link

https://absb.journals.ekb.eg/article_7175.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7175

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4

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

UTILITY OF SOME SULPHA DRUGS IN SYNTHESIS OF NEW BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS : SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL THIOSEMICARBAZIDE DERIVATIVES

Details

Type

Article

Created At

22 Jan 2023