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7170

SYNTHESIS OF SOME NOVEL THIAZOLE, AMINOTHIOPHENE, PYRIDINE, CHROMENE AND CHROMENOPYRIDINE DERIVATIVES

Article

Last updated: 03 Jan 2025

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Chemistry

Abstract

The behavior of intermediate 7 towards some α-halogenated compounds has been investigated to synthesize some novel thiophene and thiazole derivatives 9, 11, 12,14, and 15. Upon reacting 2-cyano-N'-(3, 4-dihydronaphthalen-1(2H)-ylidene) acetohydrazide (6) with acetylacetone, arylidenemalononitriles and/or CH3CHO/CH2(CN)2 afforded 2-pyridone derivatives 16,17 and 21. Treatment of compound 6 with DMF-DMA afforded N,N-dimethylaminomethylene derivative 22 which reacts with hydrazine hydrate to give α-tetraloneazine (23). Cyclocondensation of 6 with o-hydroxyacetophenone, dibromosalicyaldehyde and/or 2-hydroxyna-phthaldehyde produced chromene derivatives 26, 28a,b and 29.Treatment of 28a with CH2(CN)2 gave chromeno[3,4-c]-pyridine derivative 31.

DOI

10.21608/absb.2011.7170

Keywords

THIOPHENE, thiazole, thiazolidinone, 2-pyridones, Chromenes, chromenopyridines

Authors

First Name

MOHAMED

Last Name

HELAL

MiddleName

H.

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

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City

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Volume

22

Article Issue

Issue 1-A

Related Issue

1363

Issue Date

2011-06-01

Receive Date

2011-01-01

Publish Date

2011-06-01

Page Start

21

Page End

36

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 22_Issue Issue 1-A_Pages 21-36.pdf

PDF . 196.4kB

Link

https://absb.journals.ekb.eg/article_7170.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7170

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Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

SYNTHESIS OF SOME NOVEL THIAZOLE, AMINOTHIOPHENE, PYRIDINE, CHROMENE AND CHROMENOPYRIDINE DERIVATIVES

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Article

Created At

22 Jan 2023