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7035

EVALUATION OF SOME GROWTH FACTORS AS BIOMARKERS IN PATIENTS WITH PRIMARY AND METASTATIC LIVER CANCER

Article

Last updated: 03 Jan 2025

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Tags

Botany
Microbiology
Zoology

Abstract

Additional novel serum markers are still needed in case of malignancies such as hepatocellular carcinoma (HCC), not only for diagnosis but also for prognosis, evaluation and follow-up of the patients. Growth factors thought to be involved in the growth of both primary and metastatic malignancies such as liver cancers include transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-β) and vascular endothelial growth factor (VEGF). Therefore, the objective of this study was to evaluate their diagnostic significance as biomarkers of primary and metastatic liver cancer, their serum levels were determined by ELISA in 25 healthy persons, 25 patients with primary liver cancer and 25 patients with metastatic liver cancer. This study revealed that the serum levels of TGF-α, TGF-β1 and VEGF were significantly high (p < 0.001) in patients with primary liver cancer compared to control group. Moreover, their serum levels were much significantly higher (p < 0.001) in patients with metastatic liver cancer compared to the primary liver cancer group. These results suggest that serum levels of TGF-α, TGF-β1 and VEGF might be valuable biomarkers to predict primary cancers such as liver cancer and for predicting metastasis, as their serum levels are markedly elevated in patients with primary and metastatic malignancy.

DOI

10.21608/absb.2011.7035

Keywords

PRIMARY AND METASTATIC LIVER CANCER

Authors

First Name

ALI

Last Name

BAKR

MiddleName

M.

Affiliation

Biochemistry Department, Faculty of Oral & Dental Medicine, Misr International University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

MOTAWA

Last Name

EL HOUSSEINI

MiddleName

E.

Affiliation

Biochemistry Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

MOHAMED

Last Name

REFAIE

MiddleName

O.

Affiliation

Laboratory of Biomedical Analysis, Faculty of Science, Cairo University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

MOHAMED

Last Name

BASHANDY

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

22

Article Issue

Issue 1-C

Related Issue

1340

Issue Date

2011-06-01

Receive Date

2011-01-02

Publish Date

2011-06-01

Page Start

57

Page End

68

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 22_Issue Issue 1-C_Pages 57-68.pdf

PDF . 1.3MB

Link

https://absb.journals.ekb.eg/article_7035.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7035

Order

4

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

EVALUATION OF SOME GROWTH FACTORS AS BIOMARKERS IN PATIENTS WITH PRIMARY AND METASTATIC LIVER CANCER

Details

Type

Article

Created At

22 Jan 2023