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7373

OPTIMIZED AND VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CLOMIPRAMINE AND PAROXETINE HYDROCHLORIDE IN DRUG FORMULATIONS

Article

Last updated: 03 Jan 2025

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Tags

Chemistry

Abstract

Two simple and sensitive spectrophotometric methods have been developed for the determination of some anti-depressant drugs such as clomipramine (CLO) and paroxetine (PRX). The methods involved the formation of ion-pairs between the inorganic complexes of molybdenum(v) thiocyanate and hexakis iron(III) solution followed by extraction with 1,2- dichloroethane. The optimum conditions for the ion-pairs formation were established under which Beer,s low was obeyed for CLO and PRX in the concentration range 5-150 and 10-250 μg mL-1 for the first method, while it was obeyed for the second method in the concentration range of 10 - 200 μg mL-1 for both CLO and PRX drugs, respectively. The limits of detection were 0.0744 and 0.109 μg mL-1 and 0.177 and 0.113 μg mL-1 for CLO and PRX using the first and second methods, respectively. The limits of quantification for the first method were 0.223 and 0.531 μg mL-1 while they were 0.327 and 0.340 μg mL-1 using the second method for CLO and PRX drugs, respectively. Both of the two methods have been successfully applied for the determination of the cited drugs in row materials and in drug formulations and compared with the official reference methods. Complete validation of the proposed methods was done.

DOI

10.21608/absb.2011.7373

Volume

22

Article Issue

Issue 2-A

Related Issue

1329

Issue Date

2011-12-01

Receive Date

2018-05-20

Publish Date

2011-12-01

Page Start

159

Page End

172

Print ISSN

1110-2535

Online ISSN

2636-3305

Article File

ABSB_Volume 22_Issue Issue 2-A_Pages 159-172.pdf

PDF . 639.6kB

Link

https://absb.journals.ekb.eg/article_7373.html

Detail API

https://absb.journals.ekb.eg/service?article_code=7373

Order

20

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

OPTIMIZED AND VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CLOMIPRAMINE AND PAROXETINE HYDROCHLORIDE IN DRUG FORMULATIONS

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Type

Article

Created At

22 Jan 2023