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6419

ISOLATION AND DESCRIPTION OF ANTIMICROBIAL AND ANTI-TUMOR PRODUCED BY ACTINOMYCES SP.

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Botany
Microbiology
Zoology

Abstract

Actinomyces are one of the major group of the actinomycetes , they are important in soil biodegradation by the recycling of nutrients associated with polymers such as keratin, lignocelluloses and chitin , produce several volatile substances and exhibit diverse physiological and metabolic properties , such as the production of extracellular enzymes. Many of these secondary metabolites are potent antibiotics, which has made Streptomycetes the primary antibiotic organisms exploited by the pharmaceutical industry. Members of this group are producers, in addition of clinically useful antitumor drugs such as vancomycins,  peptides , aureolic acids , enedynes and antimetabolites and they exert antitumor activity by inducing apoptosis through DNA , inhibition of  key enzymes involved in signal transduction like proteases or cellular metabolism and  in some cases by inhibiting tumor induced angiogenesis.  Detection of radio activity of the most potent  actinomyces, optimization of production media of the promising bioactive compounds. Determination of the antitumor activity of the bioactive compounds of Actinomycetes against different tumors. 

DOI

10.21608/absb.2013.6419

Keywords

isolation, Antimicrobial, ACTINOMYCES SP

Authors

First Name

MAGED

Last Name

AHMED

MiddleName

-

Affiliation

Botany Deptartment, Faculty of Sciences, Ben Sewef University, Ben Sewef, Egypt.

Email

-

City

-

Orcid

-

First Name

RASHA

Last Name

AHMED

MiddleName

-

Affiliation

Botany Deptartment, Faculty of Sciences, Ben Sewef University, Ben Sewef, Egypt.

Email

-

City

-

Orcid

-

First Name

AHMED

Last Name

MERDASH

MiddleName

-

Affiliation

Botany Deptartment, Faculty of Sciences, Ben Sewef University, Ben Sewef, Egypt.

Email

-

City

-

Orcid

-

First Name

HUSSEIN

Last Name

EL-KABBANY

MiddleName

-

Affiliation

Health Radiation Research Department, National Center for Radiation Research and Technology. Atomic Energy Authority, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

24

Article Issue

Issue 2-C

Related Issue

1322

Issue Date

2013-12-01

Receive Date

2013-07-04

Publish Date

2013-12-01

Page Start

49

Page End

64

Print ISSN

1110-2535

Online ISSN

2636-3305

Link

https://absb.journals.ekb.eg/article_6419.html

Detail API

https://absb.journals.ekb.eg/service?article_code=6419

Order

15

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023