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6417

EVALUATION OF THE TOXIC EFFECTS OF DIFENOCONAZOLE FUNGICIDE (SCORE) ON MALE ALBINO RATS

Article

Last updated: 22 Jan 2023

Subjects

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Tags

Botany
Microbiology
Zoology

Abstract

This study was designed to estimate the LD50 of Score (difenoconazole) fungicide and evaluate its toxic effects on body weight, liver weight, some biochemical parameters and hematological profiles of male albino rats after chronic oral daily doses (1/20, 1/10 and 1/5 LD.50) for 8 weeks.
Rats were divided into 4 groups, the first group (G1) as control group, the other groups (G2, G3 and G4) treated daily with 20,40 and 80 mg/100 g.b.w. for 1, 4 and 8 weeks respectively
The medium lethal dose (LD.50) of Score was 400 mg /100g. body weight of adult male rat. Significant decreases in body weight, serum total protein, albumin, globulin, liver DNA and liver RNA, RBCs count, hemoglobin and blood Platelets count
However, significantly increase observed in hepatosomatic index, serum enzymes (ALAT, ASAT, ALP and CK), cholesterol, triglyceride, total lipids, serum creatinine and serum bilirubin and WBC's count

DOI

10.21608/absb.2013.6417

Keywords

Score, Enzymes, protein, biochemical parameters, liver DNA, liver RNA and blood profile

Authors

First Name

MOHAMED

Last Name

SHAHAT

MiddleName

M.

Affiliation

Department of Zoology, Faculty of Science, AL-Azhar University, Assiut, Egypt

Email

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City

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Orcid

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Volume

24

Article Issue

Issue 2-C

Related Issue

1322

Issue Date

2013-12-01

Receive Date

2013-07-01

Publish Date

2013-12-01

Page Start

33

Page End

48

Print ISSN

1110-2535

Online ISSN

2636-3305

Link

https://absb.journals.ekb.eg/article_6417.html

Detail API

https://absb.journals.ekb.eg/service?article_code=6417

Order

14

Type

Original Article

Type Code

520

Publication Type

Journal

Publication Title

Al-Azhar Bulletin of Science

Publication Link

https://absb.journals.ekb.eg/

MainTitle

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Details

Type

Article

Created At

22 Jan 2023