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268386

DESIGN AND SYNTHESIS OF NOVEL TERREMIDE DERIVATIVES FOR PHARMACOLOGICAL EVALUATION

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry and drug synthesis

Abstract

clinicians and chemists are directed in those days toward the biologically active compounds to reduce the mortality and morbidity. Quinazolines were reported previously as a scaffold that possesses antitumor and antimicrobial activities. Close inspection of the structure-activity-relationships (SAR) of quinazolines revealed important structural features necessary for their antimicrobial activity: a nitrogenous ring and a side chain. Using quinazoline heterocyclic compound to try to synthesize compounds similar to terremide to enhance the activity. In the present work, advantageous moieties have been combined together to generate new hybrid scaffolds of quinazoline with the objective of synthesizing new moieties enhancing the antimicrobial biological activityand drug-like properties.

DOI

10.21608/ajps.2022.268386

Keywords

Quinazoline, terramide, MRSA, Antimicrobial resistance, antitumor

Authors

First Name

Mohamed

Last Name

Elsebaei

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt.

Email

m.elsebaei@azhar.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Mancy

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt.

Email

m.elsebai@azhar.edu.eg

City

-

Orcid

-

First Name

Abdelrahman

Last Name

Mayhoub

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt. Nanoscience Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Ayman

MiddleName

-

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design Department, College of Pharmacy(boys), Al-Azhar University, Cairo 11884, Egypt.

Email

-

City

-

Orcid

-

Volume

66

Article Issue

2

Related Issue

37487

Issue Date

2022-09-01

Receive Date

2022-05-11

Publish Date

2022-09-01

Page Start

87

Page End

98

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 66_Issue 2_Pages 87-98.pdf

PDF . 373.9kB

Link

https://ajps.journals.ekb.eg/article_268386.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=268386

Order

5

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023