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187748

REVIEW ON THE SIGNIFICANCE OF QUINAZOLINE DERIVATIVES AS BROAD SPECTRUM ANTI-CANCER AGENTS.

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Medicinal chemistry and drug design

Abstract

Cancer is one of the major causes of human mortality worldwide. A number of approved antineoplastic medications and treatment regimens are already working in the field, and several new compounds are in different phases of clinical trials. An extensive series of anticancer drugs exist in the market, and studies explained that these molecules are associated with different types of adverse side effects. The reduction of the cytotoxicity of drugs to normal cells is a major problem in anticancer therapy. Therefore, researchers around the globe are involved in the development of more efficient and safer anticancer drugs. An interesting output of extensive research is that the quinazoline scaffold and its various derivatives can be explored further as a significant class of cancer chemotherapeutic agents that has already shown promising activities against different tumors. In general, quinazoline derivatives have already occupied a crucial place in modern medicinal chemistry. Quinazoline is one of the most studied moieties in medicinal chemistry due to the wide range of biological properties such as the anticancer, antibacterial, anti-inflammatory, antimalarial and antihypertensive activities. The anticancer activity of this scaffold has been well established. 

DOI

10.21608/ajps.2021.187748

Keywords

Quinazoline, Cancer, immunomodulators, thymidylate enzyme, DNA inhibition, tubulin polymerization

Authors

First Name

Mohamed

Last Name

El-Zahabi

MiddleName

-

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.

Email

malzahaby@azhar.edu.eg

City

-

Orcid

0000-0003-4538-5840

Volume

64

Article Issue

2

Related Issue

27024

Issue Date

2021-09-01

Receive Date

2021-05-18

Publish Date

2021-09-01

Page Start

21

Page End

40

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 64_Issue 2_Pages 21-40.pdf

PDF . 651.9kB

Link

https://ajps.journals.ekb.eg/article_187748.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=187748

Order

2

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

REVIEW ON THE SIGNIFICANCE OF QUINAZOLINE DERIVATIVES AS BROAD SPECTRUM ANTI-CANCER AGENTS.

Details

Type

Article

Created At

22 Jan 2023