This study is performed on six wastewater stations that discharging wastewater into Qarun lake, El-Fayoum Govenorate, Egypt, to assessment wastewater treatment on the period from April 2017 to February 2019. Sewage treatment plants use different biological treatment technologies (conventional activated sludge, oxidation ditch, aeration). In this investigation, wastewater samples were collected from the influent and effluent of each plant and transferred directly to central laboratory of Fayoum Wastewater Company for complete analysis. The obtained data reflects a large amount of drainage on the wastewater treatment stations which means high percentages of total coliform and fecal coliform. Also, the high algal content is detected at Tamiya station with total cell count 282-1210/L. Nutrients as nitrate, nitrite, ammonia and phosphate are assessed and exhibit in ranges 4.4-104.5, 0.0-8.0, 1.1-43.0 and 1.0-42.1 mg/L, respectively. On other hand, the increase of TDS and TSS were achieved during summer season. Furthermore, higher values of DO, BOD and COD considered as a strong indicator for higher microbial activity.