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86008

SYNTHESIS AND EVALUATION OF NEW ARYLAZOLES DERIVATIVES AGAINST METHICILLIN RESISTANT BACTERIA

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry and drug synthesis

Abstract

In the previously reported arylthiazole antibiotics the lipophilic part of the n-butylphenyl moiety was replaced with naphthyl ring which improved its activity against Vancomycin resistant strains of Staphylococcus aureus. In the other hand, the incorporation of the C=N linker connecting the nitrogenous head with thiazole within an oxadiazole ring provided orally available analogs with relatively long half-life. New eight derivatives of 2-(thiazol-5-yl)-1,3,4-oxadiazole was synthesized by combining both structural modifications in one new scaffold to enhance the pharmacokinetic profile and antibacterial activities against malicious microbes, two of them is comparably potent as Vancomycin.  

DOI

10.21608/ajps.2020.86008

Keywords

Arylazoles, Antimicrobial, Oxadiazole, Phenylthiazole

Authors

First Name

Mohamed

Last Name

Hannoun

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

Email

mohamehannoun.p.z@azhar.edu.eg

City

-

Orcid

-

Volume

61

Article Issue

1

Related Issue

12941

Issue Date

2020-03-01

Receive Date

2020-04-29

Publish Date

2020-03-01

Page Start

1

Page End

11

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 61_Issue 1_Pages 1-11.pdf

PDF . 739.4kB

Link

https://ajps.journals.ekb.eg/article_86008.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=86008

Order

1

Type

Review Article

Type Code

519

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023