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46644

CHOLESTASIS: MOLECULAR MECHANISM, PATHOGENESIS AND POSSIBLE MANAGEMENT

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmacology, toxicology and clinical pharmacy

Abstract

Understanding the molecular mechanism of bile formation and the different pathways and pathogenesis of drug induced cholestasis provide different possibilities for treatment. This review summarizes the role of transport proteins in hepatic drug clearance and toxicity, the involvement of inflammatory mediators in cholestasis and the role of nuclear receptors in bile acid metabolism. Understanding nuclear receptor function can help in the development of nuclear receptor ligands for treatment of cholestasis.

DOI

10.21608/ajps.2018.46644

Keywords

Bile acids, nuclear receptors, Inflammatory mediators, Management

Authors

First Name

Basant

Last Name

Al-Botaty

MiddleName

-

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

Email

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City

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Orcid

-

Volume

58

Article Issue

2

Related Issue

7238

Issue Date

2018-09-01

Receive Date

2019-09-01

Publish Date

2018-09-01

Page Start

93

Page End

114

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 58_Issue 2_Pages 93-114.pdf

PDF . 690.5kB

Link

https://ajps.journals.ekb.eg/article_46644.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=46644

Order

6

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

CHOLESTASIS: MOLECULAR MECHANISM, PATHOGENESIS AND POSSIBLE MANAGEMENT

Details

Type

Article

Created At

22 Jan 2023