The current study was designed to evaluate the modulatory effects of curcumin treatment on doxorubicin-induced nephrosis and cardiomyopathy in sprague-dawley rats. Intravenous administration of a single doxorubicin dose (7.5 mg/kg) induced apparent sings of nephrotoxicity and cardiomyopathy as manifested by marked deteriorations in both renal and cardiac parameters in association with significant changes in the histological structures of these tissues. Curcumin administration was remarkably able to mitigate the induced cardiac and kidney injuries. Moreover, it exhibited marked protective effects against such alterations.  These data suggest that curcumin may have a profound therapeutic potential against such toxic effects.