One of the most clinical assignments affecting human being in the present time is liver defect. Therefore, several factors that known to positively or negatively dealt with this organ were investigated in the present study. A 60 rats have been divided into four groups (3x6, 2x6, 3x6 and 2x6) of ten specific subgroups as follows: The control groups fed on  basal diet (G1); G2 is a high fat diet HFD containing 20% animal fat or same with 5 % of doum waste powder (HFD+DW) as G3; G4 is tetra cholro carbon (TCC) and G5 is alike received grape laves extract. In G6 animal received TPN solution, while G7 treated the same pluse lasix as duritic synthetic druge and G8 replcinng this drug with natural one. In G9 diet was contamented with afflatoxin, meanwhile, G10 was similar but a rich protein antioxidant was subleminted. It seems that the liver homeorhestic function, i.e., cortisone to insulin is governed by its homeostatic control of organ, or vice versa, hence dismutase SOD, catalase, were sharply reduced and each of GOT, GPT or AP enzymes increased with food contaminated or artificial drug administration concurantly to a sort of hormonal imbalanc. Significat repairment were noticed for feeding systemes used. These findings have been approved by organ microscopically tests. The DW, for instance, successfully decreases the influances of HFD. There were also evidence of the hepatotoxicity of TCC and of the hepatoprotective effect of the extract of grape leave juces. The minimal or maximal disruptions of the hepatocyte structure are complemented the liver enzyme data of GOT, GPT and ALP activities and other biological parameters. In case of TPN histopathology, liver of rat treated with TPN of mixed natural extract minamized the effect of TPN alone. Likewise, the microscopical  examination of liver of rat with diet contaminated of micotoxin, a highly protection for a high protein-antioxidant (HPAO) formula arises. Seemingly, feeding pattern affects hormonal oxidative balanc to perform better liver expectancy. In general conclusion, feeding pattern should be developed to help in protecting human liver, especially in poor areas allover the world. Very simple foods or even food wastes is considered hepatoprotective agents. The hormonal oxidative balance has to be further investigated in order to produce such important food that may protect liver worldwide.