The objective of this study was to formulate sustained release tablet dosage form (100 mg) using Ketoprofen Niosomes. Ketoprofen Niosomes were prepared by lipid hydration method and then dried and compressed into sustained release tablets (100 mg). The tablet excipients employed include: Avicel PH 101, Avicel PH 102, and Mannitol as diluents, Cab-O-Sil (colloidal silica) as a glidant, Starch as a disintegrant and Magnesium Stearate as lubricating agent. The tablets were tested for weight variation, hardness, friability, thickness, disintegration, drug content and release ratio. Finally the release kinetics of Ketoprofen tablets were calculated.