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7107

DESIGN, FORMULATION AND EVALUATION OF CELECOXIB SOLID DISPERSIONS PREPARED BY THE SOLVENT- EVAPORATION TECHNIQUE

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Last updated: 22 Jan 2023

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Abstract

The aim of the present study was to improve dissolution of poorly water-soluble Celecoxib by solid dispersion technique using water soluble carriers. Solid dispersions of Celecoxib were prepared with different polymers or carriers such as Hydroxy Propyl Beta Cyclodextrin,  polyvinylpyrrolidone (PVP K30) and Urea. Solid dispersions were formulated in drug polymer ratio 1:2.5, 1:5, 1:7.5 and 1:10 using solvent evaporation method. The prepared formulae were assayed for drug content, production yield and micromeritics properties. Dissolution profiles were done in water containing 1% sodium lauryl sulphate and the in-vitro release was ranked according to the % drug released after 60 and 120 minutes. The results indicated that all of the formulated solid dispersions displayed better dissolution profiles as compared to the pure drug. Formula containing drug to HP-β-CD (1:10) was ranked first and gave the best results out of the 12 solid dispersion formulae prepared.

DOI

10.21608/ajps.2013.7107

Keywords

Celecoxib, Solid dispersion, dissolution enhancement, solvent evaporation

Authors

First Name

Yasmin

Last Name

Mortagi

MiddleName

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, El-Arish, North Sinai, Egypt.

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Volume

47

Article Issue

1

Related Issue

1346

Issue Date

2013-03-01

Receive Date

2018-05-14

Publish Date

2013-03-01

Page Start

36

Page End

53

Print ISSN

1110-1644

Online ISSN

2535-1958

Link

https://ajps.journals.ekb.eg/article_7107.html

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https://ajps.journals.ekb.eg/service?article_code=7107

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4

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

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Article

Created At

22 Jan 2023