Living donor liver transplantation (LDLT) has been used for end stage liver disease (ESLD) since 1989. LDLT has basically resolved the problem of donor organ shortages. However, early complications postoperatively and long term life quality are issues that still need to be resolved. Bacterial infections remain by far the most frequently occurring infectious complication in liver transplant recipients. The main aim of the study is to point out the main risk factor for antimicrobial resistance post LDLT. In the current study, a total of 42 recipients, 7 females and 35 males who underwent LDLT at Ain Shams Center For Organ Transplantation “ASCOT". All recipients were screened for the presence of risk factors that affect patients' susceptibility to infection and hence to antimicrobial resistance either preoperative or intra operative or post operative. The observational study was done prospectively. Results obtained in the present study revealed the age of all recipients ranged from 42 to 63 years old. (mean value of 53.5 ± 6.4 years). Prolonged Operative time (P=0.016),multiple radiological interventions (P=0.040), and multiple antibiotic changes post operatively (P=0.38)   were the independent risk factors for developing infection after liver transplantation in our center. The present study confirms that infection is a frequent and major cause of morbidity and mortality after liver transplantation. Current findings suggested postoperative bacterial infections were associated with pre-, intra- and post-operative factors, so careful monitoring and management is very important to improve patients' outcome.