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DESIGN, SYNTHESIS AND EVALUATION OF SOME NOVEL 3-ALLYL-6-IODO-2-SUBSTITUTED THIOQUINAZOLINONE DERIVATIVES FOR ANTICONVULSANT ACTIVITY

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Last updated: 22 Jan 2023

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Abstract

The urgent demand for the development of new antiepileptic drug with a better efficacy inspired us to design and synthesize a new derivatives of the fused heterocyclic analogs 3-allyl-6-iodo-2-(substituted thio)quinazolin-4(3H)-one that prepared and evaluated for their anticonvulsant activity. Compounds 10, 11, 12, 13, 14 and 22 were found to be the most active anticonvulsant of this series. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues.

DOI

10.21608/ajps.2016.6950

Keywords

Synthesis, 3-allyl-6-iodo-2-(substituted thio)quinazolin-4(3H)-one, anticonvulsant screening, pentylenetetrazole

Authors

First Name

Menshawy

Last Name

Mohamed

MiddleName

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Affiliation

Department of Pharmaceutical Chemistry, College of Pharmacy, Salman bin Abdulaziz University, Alkharj, Saudi Arabia. /Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

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Volume

50

Article Issue

2

Related Issue

1333

Issue Date

2014-09-01

Receive Date

2018-05-13

Publish Date

2014-09-01

Page Start

154

Page End

172

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 50_Issue 2_Pages 154-172.pdf

PDF . 985.4kB

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https://ajps.journals.ekb.eg/article_6950.html

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https://ajps.journals.ekb.eg/service?article_code=6950

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Original Article

Type Code

518

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Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

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https://ajps.journals.ekb.eg/

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Created At

22 Jan 2023