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6893

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF ANTIBACTERIAL AND ANTIADHESIVE POTENTIALS OF SOME SUBSTITUTED IMIDAZOLONES DERIVATIVES OF CINNAMALDEHYDE

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Last updated: 03 Jan 2025

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Abstract

The cells of microorganisms often stick together and adhere to biotic and inert surfaces to form coats (biofilms) that are impenetrable and often highly resistant to antibiotics, as well as beingadaptive to immune responses of the host. The aim of this study is to develop drugs that are able to prevent cell adhesion and/or penetrate biofilm layer and reach the bacteria to render them harmless. trans-Cinnamaldehyde, found in oils and cinnamon barks, and curcumin found in turmeric have been found to hold such pharmacologic properties. The newly developed product hybrids were evaluated for their ability to exert in vitro antibacterial activity as well as their potential as bacterial anti-adhesive agents on several different bacteria. In summary, we have developed several novel compounds that show both antibacterial and anti-adhesive properties. Although the compounds are not as potent as the positive controls, they serve as lead for further structural modification to develop more potent derivatives.

DOI

10.21608/ajps.2016.6893

Keywords

Synthesis, Antibacterial, Bacterial Anti-adhesive, Biofilm, imidazolone, Cinnamaldehyde

Authors

First Name

Abdelsattar

Last Name

Omar

MiddleName

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Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah 21589, Saudi Arabia.

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Volume

53

Article Issue

1

Related Issue

1229

Issue Date

2016-03-01

Receive Date

2018-05-12

Publish Date

2016-03-01

Page Start

58

Page End

72

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 53_Issue 1_Pages 58-72.pdf

PDF . 749.9kB

Link

https://ajps.journals.ekb.eg/article_6893.html

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https://ajps.journals.ekb.eg/service?article_code=6893

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Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF ANTIBACTERIAL AND ANTIADHESIVE POTENTIALS OF SOME SUBSTITUTED IMIDAZOLONES DERIVATIVES OF CINNAMALDEHYDE

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Article

Created At

22 Jan 2023