This research aimed to 1) know about farmers' knowledge of post-harvest practices of Chamomile crop in Fayoum Governorate, 2) Determine factors affecting respondents' knowledge of post-harvest practices of Chamomile crop, 3) Identify farmers' sources of information related to post-harvest practices of the studies, and 4) Determine problems facing farmers concerning extension services and post-harvesting of the Chamomile crop in the study area. Data were collected via questionnaire forms through personal interviews with a sample of 250 respondents belonging to Al-Jilani, Shakshuk, and Kafr Aboud villages of the Ibshway district in Fayoum governorate during the period of Dec. 2021 to Jan. 2022. Frequencies, percentages, compare means “f" test, Pearson's simple correlation coefficient, stepwise regression analysis, and relative weight used for data analysis and presentation. Findings reveal that most of the respondents (82.3%) are in the highest category of knowledge of post-harvest practices of Chamomile crop. Results also show that there are eleven variables significantly correlated with farmers' knowledge of post-harvest practices of Chamomile crop: Four of them are significantly affecting farmers' knowledge, they are exporting of the production (explains 27.4% of the variance in the dependent variable), farmers' attitudes towards the private agricultural extension (explains 8.4%), farmers' social participation (explains 6%), and frequently visiting centers of agricultural services (explains 4.3%). The most used sources of farmers' information are family members, friends, and neighbors (89.5%), followed by traders (37%). Lack of extension programs for the Chamomile crop and lack of trained labor was the most frequent problems, as indicated by 87.2% and 64.8% of respondents, respectively.