The aim of the present study was to evaluate some potential therapeutic effects of peel and pulp of two eggplant varieties (round black and long white) which are widely consumed among Egyptian people using experimental rats. Peel and pulp samples were analyzed to determine the chemical composition and some minerals (Na, K and Fe). Total phenols content also were determined in addition to the identification of phenolic compounds by HPLC. The dried peel and pulp of two eggplant varieties were supplemented as 15% to the diet and used for treating diabetic, hypertensive, and hyperlipidemic rat. Thirty male albino rats weighing 140±10 g were divided to 6 groups (5 rats in each group). Five groups were given 10% fructose in the drinking water for 6 weeks to induce hypertension, hyperlipidemia and hyperinsulinemia. At the end of the experiment, Serum glucose, insulin, total cholesterol, triglycerides, lipoprotein fractions, blood pressure, serum Na, K, and MDA levels were determined in rats serum. In addition the kidney and liver of rats were removed after ether anaesthetesia and making histopathological examination. Briefly, different tested eggplant types can be considered as a good healthy food which can prevent and improve the status of hyperglycemia, hyperlipidemia, and hypertension. Peel of round black eggplant was more effective for lowering hyperlipidemia and hypertension and improved lipid profile, while the long white type was more effective for lowering hyperglycemia. These healthy effects of eggplant can be attributed to its good content of fibers, phenolic compounds, and potassium. Furthermore, the eggplant has the ability to bind with bile acids and inhibiting the activity of some enzymes as α-glucosidase and angiotensin converting the enzyme which increases hypertension.